1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

Base Information

Chemical Name:1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone
CAS No.:77815-26-0
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

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Technology Process of 1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

There total 4 articles about 1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 77815-24-8
(S)-(-)-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>ethanone

: 100-52-7
benzaldehyde

: 77815-27-1
1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

: 77815-26-0
1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

Guidance literature:: With oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Product distribution; multistep reaction: 1.) Et₂O, -78 deg C, 60 min, 2.) -78 deg C, 30 min; other solvents, temperatures; aldol condensation via lithium enolates; metal-dependent aldol condensation;
DOI:10.1021/ja00401a031

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 77815-26-0
1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

Guidance literature:: Multi-step reaction with 3 steps

2: 50 percent / diethyl ether / 5 h / Ambient temperature

3: 57 percent / 1.) di-n-butylboryl triflate, diisopropylethylamine, 3.) MoO₅*py*HMPT / multistep reaction: 1.) Et₂O, -78 deg C, 60 min, 2.) -78 deg C, 30 min; other solvents, temperatures; aldol condensation via lithium enolates; metal-dependent aldol condensation

With oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether;
DOI:10.1021/ja00401a031

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 77815-26-0
1-<1-(4-toluensulphonyl)-1-azacyclopentan-2-yl>-3-hydroxy-3-phenyl-1-propanone

Guidance literature:: Multi-step reaction with 3 steps

2: 50 percent / diethyl ether / 5 h / Ambient temperature

3: 57 percent / 1.) di-n-butylboryl triflate, diisopropylethylamine, 3.) MoO₅*py*HMPT / multistep reaction: 1.) Et₂O, -78 deg C, 60 min, 2.) -78 deg C, 30 min; other solvents, temperatures; aldol condensation via lithium enolates; metal-dependent aldol condensation

With oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether;
DOI:10.1021/ja00401a031