Benzothiazole, 5-chloro-2-(methylthio)- (7CI,8CI,9CI)

Base Information

• Chemical Name: Benzothiazole, 5-chloro-2-(methylthio)- (7CI,8CI,9CI)
• CAS No.: 3507-41-3
• Molecular Formula: C8H6ClNS2
• Molecular Weight: 214.96
• Hs Code.: 2934999090
• Mol file: 3507-41-3.mol

Synonyms:5-Chloro-2-(methylthio)benzothiazole;5-Chloro-2-methylsulfanylbenzothiazole;

Chemical Property of Benzothiazole, 5-chloro-2-(methylthio)- (7CI,8CI,9CI)

Chemical Property:

• Melting Point: 73 °C
• Boiling Point: 337.584 °C at 760 mmHg
• PKA: 0.72±0.10(Predicted)
• Flash Point: 157.965 °C
• PSA: 66.43000
• Density: 1.451 g/cm³
• LogP: 3.67160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2-(methylthio)benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 5-chloro-2-(methylthio)- (7CI,8CI,9CI)

There total 8 articles about Benzothiazole, 5-chloro-2-(methylthio)- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 5-Chloro-2-(methylthio)benzothiazole (3507-41-3)

Guidance literature:

Reference yield: 96.0%

5-chloro-2-mercaptobenzothiazole (5331-91-9) + methyl iodide (74-88-4) → 5-Chloro-2-(methylthio)benzothiazole (3507-41-3)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 1h;

DOI:10.1002/cbdv.201000241

Reference yield:

5-chloro-1,3-benzothiazole-2(3H)-thione (5331-91-9) + methyl iodide (74-88-4) → 5-Chloro-2-(methylthio)benzothiazole (3507-41-3)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

5-chloro-1,3-benzothiazole-2(3H)-thione

methyl iodide

5-chloro-2-mercaptobenzothiazole

dimethyl sulfate

Downstream raw materials:

5-chloro-1,3-benzothiazol-2(3H)-one

(5-chloro-1,3-benzothiazol-2-yl)hydrazine

2-(5-chlorobenzothiazol-2-yl)-1,2-dihydro-5-phenyl-3H-pyrazol-3-one

2-(5-chlorobenzothiazol-2-yl)-4-[1-dimethylaminomethylidene]-5-phenyl-2,4-dihydropyrazol-3-one

Refernces

• 1、 Bertron, Jeanette L.,Gestwicki, Jason E.,Hayashi, Shigenari,Li, Xiaokai,Schwarz, Daniel M. C.,Shao, Hao,Tang, Benjamin C.. "Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels". . . Retrieved 2021/04/22.
• 2、 -. "AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY". Page/Page column 29; 30. . Retrieved 2013/09/26.