1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride

Base Information

• Chemical Name: 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride
• CAS No.: 91979-38-3
• Molecular Formula: C₆H₉ClN₂*ClH
• Molecular Weight: 181.065
• Mol file: 91979-38-3.mol

Synonyms:1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride

Chemical Property of 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride

Chemical Property:

Purity/Quality:

MC004686:1-Chloromethyl-3,5-dimethyl-1H-pyrazole,hydrochloride 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride

There total 2 articles about 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(Hydroxymethyl)-3,5-dimethylpyrazole (85264-33-1) → 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride (91979-38-3)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Ambient temperature;

Reference yield:

3,5-dimethyl-1H-pyrazole (67-51-6) → 1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride (91979-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / ethanol; H₂O / 1.) reflux, 1 h, 2.) RT, 12 h

2: 98 percent / thionyl chloride / CHCl₃ / 3 h / Ambient temperature

With thionyl chloride; In ethanol; chloroform; water;

Reference yield: 99.0%

1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride (91979-38-3) + diphenylphosphane (829-85-6) → 1-[(diphenylphosphanyl)methyl]-3,5-dimethylpyrazole

Guidance literature:

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at -77 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

1-chloromethyl-3,5-dimethyl-1H-pyrazole hydrochloride; In tetrahydrofuran; hexane; at -77 - 20 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2015.10.007

upstream raw materials:

1-(Hydroxymethyl)-3,5-dimethylpyrazole

3,5-dimethyl-1H-pyrazole

Downstream raw materials:

1-(3-cyano-4,6-diphenylpyrid-2-yl)oxymethyl-3,5-dimethyl-1H-pyrazole

1-(3-cyano-4,6-diphenylpyrid-2-on-1-yl)methyl-3,5-dimethyl-1H-pyrazole

1-ethoxymethyl-3,5-dimethyl-1H-pyrazole

1-(phenylthio)methyl-3,5-dimethyl-1H-pyrazole