1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:78946-22-2
Molecular Formula:C₁₉H₂₂BrNO₂
Molecular Weight:376.293
Hs Code.:

Synonyms:1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 51714-24-0
6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

: 589-15-1
1-bromomethyl-4-bromobenzene

: 78946-22-2
1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile; With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; ethanol; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00652

Reference yield: 48.0%

: 30045-07-9
2-methyl-6,7-dimethoxy-3,4-dihydroisoquinolinium iodide

: 589-15-1
1-bromomethyl-4-bromobenzene

: 78946-22-2
1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: electroreduction;
DOI:10.1016/S0040-4039(01)82914-2

Reference yield:

: 608141-08-8
1-(4-bromo-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

: 78946-22-2
1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: zinc-powder; water; acetic acid

2: water; formic acid

With formic acid; water; acetic acid; zinc;