3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

Base Information

Chemical Name:3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester
CAS No.:372523-30-3
Molecular Formula:C₂₄H₂₁Cl₂NO₆S
Molecular Weight:522.406
Hs Code.:

Synonyms:3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

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Chemical Property of 3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

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Technology Process of 3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

There total 7 articles about 3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 372523-17-6
3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]-5-ethylphenyl ester

: 372523-30-3
3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

Guidance literature:: With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm010833f

Reference yield:

: 51863-60-6
3,5-dihydroxyacetophenone

: 372523-30-3
3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / H₂; aq. HCl / Pd/C / 16 h / 20 °C

2: 22 percent / aq. NaHCO₃ / diethyl ether / 48 h / 20 °C

3: 17 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

4: 52 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; 3: Mitsunobu reaction;
DOI:10.1021/jm010833f

Reference yield:

: 19116-94-0
3,5-dichloro-2-methoxybenzene-1-sulfonyl chloride

: 372523-30-3
3,5-dichloro-2-methoxybenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 22 percent / aq. NaHCO₃ / diethyl ether / 48 h / 20 °C

2: 17 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

3: 52 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 2: Mitsunobu reaction;
DOI:10.1021/jm010833f