N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

Base Information

Chemical Name:N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide
CAS No.:168046-41-1
Molecular Formula:C₃₇H₃₇N₅O₄
Molecular Weight:615.732
Hs Code.:

N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

Synonyms:N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

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Chemical Property of N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

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Technology Process of N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

There total 10 articles about N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 109-01-3
1-methyl-piperazine

: 168046-06-8
2-<2,6-diaza-6-<<4<<2-(4-methylphenyl)phenyl>carbonyl-amino>phenyl>carbonyl>-3-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>acetic acid

: 168046-41-1
N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;
DOI:10.1248/cpb.47.501

Reference yield:

: 5755-07-7
2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

: 168046-41-1
N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) THF, RT, overnight

3: 99 percent / Fe, AcOH / methanol / 1 h / Heating

4: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

5: 95 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

6: 96 percent / 1-hydroxybenzotriazole, 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 1.5 h / Ambient temperature

With sodium hydroxide; iron; sodium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.501

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 168046-41-1
N-<4-<2,6-diaza-6-<2-(4-methylpiperazinyl)-2-oxoethyl>-5-oxobicyclo<5.4.0>undeca-1(7),8,10-trien-2-yl>carbonyl>phenyl<2-(4-methylphenyl)phenyl>formamide

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

2: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

3: 95 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature

4: 96 percent / 1-hydroxybenzotriazole, 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 1.5 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.501