{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

Base Information

Chemical Name:{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester
CAS No.:245660-28-0
Molecular Formula:C₂₇H₄₄N₂O₆Si
Molecular Weight:520.742
Hs Code.:

Synonyms:{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

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Chemical Property of {2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

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Technology Process of {2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

There total 4 articles about {2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 245660-16-6
5-((tert-butyldimethylsilyl)oxy)pentan-1-amine

: 245660-14-4
{2S-[2α,3β(S)]}-3({[3-Phenyl-1-(carboxyl)propyl]amino}carbonyl)oxirane carboxylic acid ethyl ester

: 245660-28-0
{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 0 - 23 ℃; for 10h;
DOI:10.1055/s-1999-3648

Reference yield:

: 63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7
ethyl (2S,3S)-2,3-epoxysuccinate

: 245660-28-0
{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / EDC; HOBT; N-methylmorpholine / CHCl₃ / 10 h / 0 - 23 °C

2: 95 percent / H₂ / 10 percent Pd/C / methanol; ethyl acetate / 0.17 h / 2068.59 Torr

3: 66 percent / EDC; HOBT; N-methylmorpholine / CHCl₃ / 10 h / 0 - 23 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; chloroform; ethyl acetate; 1: Acylation / 2: Hydrogenolysis / 3: Acylation;
DOI:10.1055/s-1999-3648

Reference yield:

: 117560-24-4
p-tolylsulfonic caid salt of L-homophenylalanine benzyl ester

: 245660-28-0
{2S-[2α,3β(S)]}-3-{[(3-Phenyl-1-{[(5-t-butyldimethylsilanoxylpentyl)amino]carbonyl}propyl)amino]carbonyl}oxirane carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / EDC; HOBT; N-methylmorpholine / CHCl₃ / 10 h / 0 - 23 °C

2: 95 percent / H₂ / 10 percent Pd/C / methanol; ethyl acetate / 0.17 h / 2068.59 Torr

3: 66 percent / EDC; HOBT; N-methylmorpholine / CHCl₃ / 10 h / 0 - 23 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; chloroform; ethyl acetate; 1: Acylation / 2: Hydrogenolysis / 3: Acylation;
DOI:10.1055/s-1999-3648