(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

Base Information

Chemical Name:(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)
CAS No.:110450-57-2
Molecular Formula:C₁₃H₁₉NO₆S₂
Molecular Weight:349.429
Hs Code.:

Synonyms:(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

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Chemical Property of (2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

Chemical Property:

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Technology Process of (2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

There total 3 articles about (2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110005-19-1
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol

: 98-59-9
p-toluenesulfonyl chloride

: 110450-57-2
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

Guidance literature:: With pyridine; at -25 ℃;
DOI:10.1246/cl.1986.2061

Reference yield:

: 33996-30-4
trans-4-hydroxy-L-proline ethyl ester hydrochloride

: 110450-57-2
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / anh. pyridine / a) 0 deg C, 6 h, b) RT, 15 h

2: 87 percent / LiAlH₄ / tetrahydrofuran / a) 0 deg C, 3 h, b) RT, 3 h

3: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1248/cpb.42.481

Reference yield:

: 110005-18-0
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinecarboxylic acid ethyl ester

: 110450-57-2
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / LiAlH₄ / tetrahydrofuran / a) 0 deg C, 3 h, b) RT, 3 h

2: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1248/cpb.42.481