(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

Base Information

Chemical Name:(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran
CAS No.:385809-10-9
Molecular Formula:C₁₈H₂₆O₄S
Molecular Weight:338.468
Hs Code.:

Synonyms:(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

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Chemical Property of (R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

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Technology Process of (R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

There total 14 articles about (R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 385809-11-0
[3R,5S]-[5-(1R,S)-(1-ethoxyallyloxy)-3-methyl-oct-7-ene-1-yl-sulfonyl]benzene

: 385809-10-9
(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: [3R,5S]-[5-(1R,S)-(1-ethoxyallyloxy)-3-methyl-oct-7-ene-1-yl-sulfonyl]benzene; Grubbs catalyst first generation; In dichloromethane; at 40 ℃;

With ethanol; pyridinium p-toluenesulfonate; at 20 ℃; for 16h;
DOI:10.1002/1521-3773(20011015)40:20<3842::AID-ANIE3842>3.0.CO;2-R

Reference yield:

: 385809-08-5
(2R)-2-[(2R)-(2-methyl-4-phenylsullfanyl-butyl)]oxirane

: 385809-10-9
(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / MMPP / ethanol / 1.5 h / 10 °C

2: DIBAL / CH₂Cl₂ / -78 °C

3: PPTS / 16 h / 20 °C

With pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In ethanol; dichloromethane;
DOI:10.1002/1521-3773(20011015)40:20<3842::AID-ANIE3842>3.0.CO;2-R

Reference yield:

: 527742-73-0
(6S)-6-(tert-butyldimethylsilanyloxymethyl)-5,6-dihydro-2H-pyran-2-one

: 385809-10-9
(R)-2-((R)-4-Benzenesulfonyl-2-methyl-butyl)-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / diethyl ether / 1 h / 0 °C

2: 98 percent / LiBH₄ / tetrahydrofuran / 17 h / 0 - 20 °C

3: 83 percent / nBu₃P / 17 h / 0 - 20 °C

4: Et₃N / CH₂Cl₂ / 1 h / -10 - 20 °C

5: TBAF / tetrahydrofuran / 1 h / 0 °C

6: 15 percent aq. NaOH / 1 h / 0 °C

7: 89 percent / MMPP / ethanol / 1.5 h / 10 °C

8: DIBAL / CH₂Cl₂ / -78 °C

9: PPTS / 16 h / 20 °C

With sodium hydroxide; lithium borohydride; tributylphosphine; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1002/1521-3773(20011015)40:20<3842::AID-ANIE3842>3.0.CO;2-R