2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Base Information

Chemical Name:2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester
CAS No.:852292-56-9
Molecular Formula:C₂₃H₂₃NO₆S
Molecular Weight:441.505
Hs Code.:

Synonyms:2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Suppliers and Price of 2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

There total 4 articles about 2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 852292-44-5
4-methyl-N-[4-methyl-2-(3-oxo-prop-1-ynyl)-phenyl]-benzenesulfonamide

: 65434-72-2
2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester

: 852292-56-9
2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: In chloroform; toluene; at 20 ℃; for 48h;
DOI:10.1055/s-2005-863741

Reference yield:

: 29289-13-2
2-iodo-4-methylaniline

: 852292-56-9
2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: Et₃N; CuI / (Ph₃P)2PdCl₂ / tetrahydrofuran

3: 100 percent / MnO₂ / CH₂Cl₂ / 8 h / 20 °C

4: 89 percent / toluene; CHCl₃ / 48 h / 20 °C

With pyridine; manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; toluene; 2: Sonogashira coupling / 4: Wittig reaction;
DOI:10.1055/s-2005-863741

Reference yield:

: 852292-23-0
N-(2-iodo-4-methylphenyl)-4-methylbenzenesulfonamide

: 852292-56-9
2-[3-[5-Methyl-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; CuI / (Ph₃P)2PdCl₂ / tetrahydrofuran

2: 100 percent / MnO₂ / CH₂Cl₂ / 8 h / 20 °C

3: 89 percent / toluene; CHCl₃ / 48 h / 20 °C

With manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; toluene; 1: Sonogashira coupling / 3: Wittig reaction;
DOI:10.1055/s-2005-863741