tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate
CAS No.:1610520-52-9
Molecular Formula:C₂₈H₃₇N₃O₅S
Molecular Weight:527.685
Hs Code.:

Synonyms:tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

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Chemical Property of tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

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Technology Process of tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

There total 5 articles about tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1610520-45-0
7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 574007-62-8,688363-66-8,180975-66-0,574007-66-2
tert-butyl 2,6-dimethylpiperazine-1-carboxylate

: 1610520-52-9
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 40 ℃; for 3h;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610520-52-9
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water;

Reference yield:

: 1610520-27-8
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 1610520-52-9
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)-2,6-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

2.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

4.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;