1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6R)-

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6R)-
• CAS No.: 574007-62-8
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30500
• Hs Code.: 2933599590
• Mol file: 574007-62-8.mol

Synonyms:1-Piperazinecarboxylic acid, 2,6-dimethyl-, 1,1-dimethylethyl ester, (2R,6R)-;

Chemical Property of 1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6R)-

Chemical Property:

• Vapor Pressure: 0.00394mmHg at 25°C
• Boiling Point: 279.7±15.0 °C(Predicted)
• PKA: 8.53±0.60(Predicted)
• PSA: 41.57000
• Density: 0.970±0.06 g/cm3(Predicted)
• LogP: 1.87040
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(2R,6R)-tert-Butyl2,6-dimethylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6R)-

There total 7 articles about 1-Piperazinecarboxylic acid, 2,6-diMethyl-, 1,1-diMethylethyl ester, (2R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8) → tert-butyl 2,6-dimethylpiperazine-1-carboxylate (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 3040.2 Torr;

Reference yield: 98.0%

→ (2R,6R)-tert-butyl 2,6-dimethylpiperazine-1-carboxylate (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 - 60 ℃; for 18h; Inert atmosphere;

Reference yield: 97.8%

4-benzyl 1-(tert-butyl) (2R,6S)-2,6-dimethylpiperazine-1,4-dicarboxylate (2080367-38-8) → (2R,6S)-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 17h;

upstream raw materials:

benzyl (3S,5R)-3,5-dimethylpiperazine-1-carboxylate

cis-2,6-dimethylpiperazine

4-benzyl 1-(tert-butyl) (2R,6S)-2,6-dimethylpiperazine-1,4-dicarboxylate

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate