(4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Base Information

Chemical Name:(4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde
CAS No.:128990-45-4
Molecular Formula:C₂₅H₃₀O₆
Molecular Weight:426.51
Hs Code.:

Synonyms:(4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Suppliers and Price of (4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

There total 34 articles about (4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 128990-44-3,128990-47-6,128990-48-7,128990-53-4,129006-12-8,129006-13-9,129006-14-0,129006-15-1
Acetic acid ((4S,5S,4'S,5'S)-5'-benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-phenylsulfanyl-methyl ester

: 128990-45-4
(4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4020(01)97596-9

Reference yield: 65.0%

: 128990-44-3,128990-47-6,128990-48-7,128990-53-4,129006-12-8,129006-13-9,129006-14-0,129006-15-1
Acetic acid ((4R,5R,4'S,5'S)-5'-benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-phenylsulfanyl-methyl ester

: 128990-40-9,128990-45-4,128990-46-5,128990-49-8,128990-50-1,128990-51-2,128990-52-3
(4R,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Guidance literature:: With potassium carbonate; In methanol; Ambient temperature;
DOI:10.1016/S0040-4020(01)97596-9

Reference yield:

: 128990-34-1
(E)-4-(benzhydryloxy)but-2-enal

: 128990-45-4
(4S,5S,4'S,5'S)-5'-Benzhydryloxymethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-carbaldehyde

Guidance literature:: Multi-step reaction with 15 steps

1: 100 percent / NaBH₄ / methanol / 3 h / -20 - -10 °C

2: 92 percent / t-BuOCl, L-(+)-diisopropyl tartrate*Ti(OiPr)4 / CH₂Cl₂ / -20 °C

3: 71 percent / 0.5N NaOH / 2-methyl-propan-2-ol / Heating

4: POCl₃ / CH₂Cl₂ / Ambient temperature

5: m-chloroperoxybenzoic acid / CH₂Cl₂ / -78 °C

6: NaOAc / 8 h / Heating

7: 91 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 0.5 h / -78 °C

8: 88 percent / benzene / Ambient temperature

9: 91 percent / NaBH₄ / methanol / -20 - -10 °C

10: 76 percent / t-BuOCl, L-(+)-diisopropyl tartrate, Ti(OiPr)4 / CH₂Cl₂ / -20 °C

11: 0.5N NaOH / 2-methyl-propan-2-ol / Heating

12: d-10-Camphersulfonic acid / CH₂Cl₂ / Ambient temperature

13: m-chloroperoxybenzoic acid / CH₂Cl₂ / -78 °C

14: NaOAc / Heating

15: 81 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / -78 °C

With titanium(IV) isopropylate; sodium hydroxide; sodium tetrahydroborate; tert-butylhypochlorite; L-(+)-diisopropyl tartrate; L-(+)-diisopropyl tartrate*Ti(OiPr)4; sodium acetate; diisobutylaluminium hydride; (+)-10-camphorsulfonic acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In methanol; hexane; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)97596-9