2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Base Information

Chemical Name:2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate
CAS No.:155351-73-8
Molecular Formula:C₁₆H₂₁F₃O₈S
Molecular Weight:430.399
Hs Code.:

Synonyms:2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

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Technology Process of 2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

There total 6 articles about 2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 155351-72-7
2-hydroxy-3-methoxy-5-<5-(methoxymethoxy)ethyl>benzaldehyde trimethylene acetal

: 155351-73-8
2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 0.166667h;
DOI:10.1021/ja00082a023

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 155351-73-8
2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 87.8 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

4: 99.5 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

5: 2.08 g / HCO₂NH₄, 10percent Pd/C / methanol / 0.17 h / Ambient temperature

6: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

With palladium on activated charcoal; n-butyllithium; ammonium formate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja00082a023

Reference yield:

: 155351-68-1
2-O-benzyl-5-bromo-2-hydroxy-3-methoxybenzaldehyde

: 155351-73-8
2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

3: 99.5 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

4: 2.08 g / HCO₂NH₄, 10percent Pd/C / methanol / 0.17 h / Ambient temperature

5: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

With palladium on activated charcoal; n-butyllithium; ammonium formate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; benzene;
DOI:10.1021/ja00082a023