methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate

Base Information

• Chemical Name: methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate
• CAS No.: 1416276-15-7
• Molecular Formula: C₁₇H₁₅NO₃S
• Molecular Weight: 313.377

Synonyms:methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate

Chemical Property of methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate

Chemical Property:

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Technology Process of methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate

There total 2 articles about methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,2'-dithiodibenzoyl bis-phenylalanine methyl ester → methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate (1416276-15-7)

Guidance literature:

With bromine; triethylamine; In dichloromethane; for 0.583333h;

DOI:10.1016/j.bmc.2012.10.058

Reference yield:

2,2'-dithiobenzoic acid (119-80-2) → methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate (1416276-15-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / 20 °C / Reflux

2: triethylamine / 20 °C

3: triethylamine; bromine / dichloromethane / 0.58 h

With bromine; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.10.058

Reference yield: 44.0%

methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acetate (1416276-15-7) → 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acid (1212403-91-2)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2012.10.058

upstream raw materials:

2,2'-dithiobenzoic acid

Downstream raw materials:

2-[2-phenyl-1-(2-p-ethoxyphenyl-1,3,4-oxadiazol-5-yl)ethyl]-1,2-benzisothiazol-3(2H)-one

2-[2-phenyl-1-(2-p-pyridyl-1,3,4-oxadiazol-5-yl)ethyl]-1,2-benzisothiazol-3-one

2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-3-phenylpropanoic acid

2-[2-phenyl-1-(2-p-methoxyphenyl-1,3,4-oxadiazol-5-yl)ethyl]-1,2-benzisothiazol-3(2H)-one

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