(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

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Chemical Name:(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate
CAS No.:1562199-65-8
Molecular Formula:C₂₉H₂₆BrN₅O₄
Molecular Weight:588.461
Hs Code.:

Synonyms:(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

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Chemical Property of (S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

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Technology Process of (S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

There total 5 articles about (S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562193-27-4
2-(3-(bromomethyl)-6-bromo-1H-indazol-1-yl)benzonitrile

: 99197-80-5
(S)-tert-butyl (4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepine-3-yl)aminoformate

: 1562199-65-8
(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

: 1562199-65-8
(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.75 h

3: caesium carbonate / N,N-dimethyl-formamide / 70 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1562199-65-8
(S)-tert-butyl 5-((6-bromo-1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 3 h / 0 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1.75 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide; mineral oil;