(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Base Information

Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid
CAS No.:99197-78-1
Molecular Formula:C₁₄H₁₈N₂O₇
Molecular Weight:326.306
Hs Code.:
Mol file:99197-78-1.mol

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Suppliers and Price of (S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
N-Boc-O-(2-nitrophenyl)-L-serine 97%
0.5g
$ 440.00

Total 4 raw suppliers

Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-O-(2-nitrophenyl)-L-serine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

There total 4 articles about (S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Guidance literature:: (S)-N-(tert-butoxycarbonyl)serine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;

ortho-nitrofluorobenzene; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 3h;
DOI:10.1021/jm400731m

Reference yield: 70.7%

: N-tert-butyloxy-L-serine

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Guidance literature:: N-tert-butyloxy-L-serine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 3h;

ortho-nitrofluorobenzene; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 4.33333h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane; water / 20 °C / Cooling with ice

2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With sodium hydride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;