1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

Base Information

Chemical Name:1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol
CAS No.:1333477-15-8
Molecular Formula:C₄₇H₄₇Cl₃NO₁₃P
Molecular Weight:971.222
Hs Code.:

1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

Synonyms:1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

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Chemical Property of 1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

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Technology Process of 1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

There total 4 articles about 1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1333477-19-2
1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]-2-(tert-butyldimethylsilyloxy)ethane

: 1333477-15-8
1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.carres.2011.05.018

Reference yield: 20.0%

: 1333477-14-7
6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranosyl trichloroacetimidate

: 107-21-1
ethylene glycol

: 1333477-15-8
1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

: 1333477-16-9
1,2 di-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethane

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; at 20 ℃; Molecular sieve; Inert atmosphere;
DOI:10.1016/j.carres.2011.05.018

Reference yield:

: 6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose

: 1333477-15-8
1-[6-O-benzyl-2-deoxy-4-O-(di-O-benzylphosphono)-3-O-(9-fluorenylmethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranosyloxy]ethan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / dichloromethane; mineral oil / 1 h / 20 °C

2: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran; dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.carres.2011.05.018