N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1613627-74-9
Molecular Formula:C₂₄H₂₂ClN₃O
Molecular Weight:403.911
Hs Code.:

Synonyms:N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

There total 5 articles about N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1334717-18-8
N-(([1,1'-biphenyl]-4-yl)methyl)-6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxamide

: 74-88-4
methyl iodide

: 1613627-74-9
N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: N-(([1,1'-biphenyl]-4-yl)methyl)-6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm5003606

Reference yield:

: 1334721-53-7
ethyl 6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylate

: 1613627-74-9
N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / ethanol / 20 °C / Inert atmosphere

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5003606

Reference yield:

: 1216142-18-5
6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylic acid

: 1613627-74-9
N-([1,1'-biphenyl]-4-ylmethyl)-6-chloro-2-ethyl-N-methylimidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm5003606