2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide

Base Information

• Chemical Name: 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide
• CAS No.: 882423-45-2
• Molecular Formula: C₂₆H₂₈N₂O₂
• Molecular Weight: 400.521
• Mol file: 882423-45-2.mol

Synonyms:2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide

Chemical Property of 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide

There total 1 articles about 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C7H7NO(2-)*2Li(1+) + N-allyl-N-benzylphenylalanine methyl ester (183155-30-8) → 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide (882423-45-2)

Guidance literature:

In tetrahydrofuran;

DOI:10.3987/COM-05-S(T)52

Reference yield: 80.0%

2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide (882423-45-2) + methyl iodide (74-88-4) → 2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-N-methyl-3-phenyl-propionamide (882423-47-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.3987/COM-05-S(T)52

Reference yield:

2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-3-phenyl-propionamide (882423-45-2) → (2,3-dibenzyl-3-aza-bicyclo[3.1.0]hex-1-yl)-(4-methoxy-phenyl)-methyl-amine

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH / tetrahydrofuran

2: 68 percent / ClTi(O-i-Pr)3; c-C₅H₁₁MgCl / tetrahydrofuran

With triisopropoxytitanium(IV) chloride; c-C₅H₁₁MgCl; sodium hydride; In tetrahydrofuran;

DOI:10.3987/COM-05-S(T)52

upstream raw materials:

N-allyl-N-benzylphenylalanine methyl ester

Downstream raw materials:

2-(allyl-benzyl-amino)-N-(4-methoxy-phenyl)-N-methyl-3-phenyl-propionamide