Technology Process of [2-(2,6-dichloro-4-hydroxyphenylamino)-phenyl-[3,4,5,6-D4]]-essigs?ure-[1,1-D2]
There total 4 articles about [2-(2,6-dichloro-4-hydroxyphenylamino)-phenyl-[3,4,5,6-D4]]-essigs?ure-[1,1-D2] which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; ascorbic acid;
In
aq. phosphate buffer;
at 20 ℃;
pH=7;
Kinetics;
Enzymatic reaction;
DOI:10.1002/jlcr.3103
- Guidance literature:
-
Multi-step reaction with 2 steps
1: deuteromethanol; [D]-sodium hydroxide / water-d2 / 0 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube
2: ascorbic acid; dihydrogen peroxide / aq. phosphate buffer / 20 °C / pH 7 / Enzymatic reaction
With
[D]-sodium hydroxide; deuteromethanol; dihydrogen peroxide; ascorbic acid;
In
aq. phosphate buffer; water-d2;
DOI:10.1002/jlcr.3103
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen chloride; water-d2 / 0.33 h / 160 °C / Microwave irradiation
2: potassium tetrachloroplatinate(II); water-d2; deuteroacetic acid / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation
3: deuteromethanol; [D]-sodium hydroxide / water-d2 / 0 h / 130 °C / Inert atmosphere; Microwave irradiation
4: Cunninghamella echinulata ATCC 9245 / acetone; ethanol; water / 168 h
With
potassium tetrachloroplatinate(II); [D]-sodium hydroxide; deuteromethanol; deuteroacetic acid; water-d2; hydrogen chloride;
In
ethanol; water; water-d2; acetone;
DOI:10.1016/j.bmc.2012.06.052
![[2-(2,6-dichloro-phenylamino-[4-D])-phenyl-[3,4,5,6-D<sub>4</sub>]]-essigs?ure-[1,1-D<sub>2</sub>]](/Databaselist/images/loading.webp)
