ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate

Base Information

• Chemical Name: ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate
• CAS No.: 160097-41-6
• Molecular Formula: C₂₄H₂₆O₈
• Molecular Weight: 442.466
• Mol file: 160097-41-6.mol

Synonyms:ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate

Chemical Property of ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate

There total 2 articles about ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-formyl-2-methoxyphenoxy)-4-hydroxy-5-methoxybenzaldehyde (2555-98-8) → ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate (160097-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂

2: NaH / tetrahydrofuran / 1 h

With pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

4-hydroxy-3-(4-hydroxymethyl-2-methoxyphenoxy)-5-methoxybenzaldehyde (160097-39-2) → ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate (160097-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / DDQ / tetrahydrofuran / Ambient temperature

2: 84 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂

3: NaH / tetrahydrofuran / 1 h

With pyridinium p-toluenesulfonate; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane;

Reference yield: 80.0%

ethyl (E)-3-<4-<(E)-2-ethoxycarbonylvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamate (160097-41-6) → (E)-3-<4-<(E)-2-carboxyvinyl>-2-methoxyphenoxy>-4-hydroxy-5-methoxycinnamic acid

Guidance literature:

With sodium hydroxide; water; In 1,4-dioxane;

upstream raw materials:

3-(4-formyl-2-methoxyphenoxy)-4-hydroxy-5-methoxybenzaldehyde

4-hydroxy-3-(4-hydroxymethyl-2-methoxyphenoxy)-5-methoxybenzaldehyde