22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

Base Information

Chemical Name:22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane
CAS No.:135638-85-6
Molecular Formula:C₃₅H₅₃N₃O₉
Molecular Weight:659.821
Hs Code.:

Synonyms:22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

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Chemical Property of 22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

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Technology Process of 22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

There total 6 articles about 22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 129245-21-2
O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine

: 135638-84-5
N-(benzyloxy)-N-(3,6,9-trioxadecyl)succinamic acid

: 135638-85-6
22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 17h;
DOI:10.1021/jm00115a006

Reference yield:

: N-(5-Aminopentyl)-N-(tort-butoxycarbonyl)-O-benzylhydroxylamine

: 135638-84-5
N-(benzyloxy)-N-(3,6,9-trioxadecyl)succinamic acid

: 129245-22-3
N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid

: 135638-85-6
22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

Guidance literature:: With diphenylphosphoranyl azide;

Reference yield:

: 62921-74-8,518012-62-9,58320-73-3
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

: 135638-85-6
22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, 72 deg C, 18 h

2: 91 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / 0 - 20 °C

3: 92 percent / pyridine / 2 h / 90 °C

4: 94 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 17 h / 0 - 20 °C

With pyridine; diphenyl phosphoryl azide; sodium hydride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a006