1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Base Information

Chemical Name:1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene
CAS No.:440368-22-9
Molecular Formula:C₃₇H₅₀Br₂OSi
Molecular Weight:698.697
Hs Code.:

Synonyms:1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Suppliers and Price of 1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

There total 6 articles about 1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 440368-51-4
3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-carboxaldehyde

: 558-13-4
carbon tetrabromide

: 440368-22-9
1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Guidance literature:: With triphenylphosphine; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1021/jm050271q

Reference yield:

: 862259-68-5
3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-methanol

: 440368-22-9
1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

2: 93 percent / PPh₃ / CH₂Cl₂ / 0.33 h / 0 °C

With triphenylphosphine; pyridinium chlorochromate; In dichloromethane; 2: Corey-Fuchs reaction;
DOI:10.1021/jm050271q

Reference yield:

: 862259-67-4
3α-(tert-butyldiphenylsilyloxy)-5α-pregnan-20-one

: 440368-22-9
1,1-dibromo-2-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]ethylene

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaOBr / dioxane; H₂O / 24 h / 20 °C

2: 73.5 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

3: 93 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

4: 93 percent / PPh₃ / CH₂Cl₂ / 0.33 h / 0 °C

With lithium aluminium tetrahydride; sodium hypobromide; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 4: Corey-Fuchs reaction;
DOI:10.1021/jm050271q