N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:1345847-81-5
Molecular Formula:C₂₂H₁₅Cl₂F₂N₃O₃
Molecular Weight:478.282
Hs Code.:

Synonyms:N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 8 articles about N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbonyl chloride

: 1225278-69-2
5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl amine

: 1345847-81-5
N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1345847-81-5
N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / -15 °C / Inert atmosphere

1.2: 16 h / -15 °C

2.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 3 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

With sodium hydride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 113020-21-6
1,1-cyclopropanedicarboxylic acid monomethyl ester

: 1345847-81-5
N-(5-chloro-4-(2-chloropyridin-4-yloxy)-2-fluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

2.2: pH 5 / Cooling with ice

3.1: thionyl chloride / 0.5 h / 60 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

With thionyl chloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;