C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

Base Information

Chemical Name:C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine
CAS No.:867273-41-4
Molecular Formula:C₂₀H₂₆N₂O₂
Molecular Weight:326.439
Hs Code.:

Synonyms:C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

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Technology Process of C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

There total 5 articles about C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 867273-40-3
C₂₀H₂₂N₆O₂

: 867273-41-4
C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; under 760 Torr;
DOI:10.1055/s-2005-871963

Reference yield:

: Methanesulfonic acid (1S,2S,3S,4S)-2-methanesulfonyloxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutylmethyl ester

: 867273-41-4
C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaN₃ / dimethylformamide / Heating

2: 86 percent / H₂ / Pd/C / 760 Torr

With sodium azide; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1055/s-2005-871963

Reference yield:

: 5248-12-4
anti head-to-head coumarin dimer

: 867273-41-4
C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / aq. KOH / acetone

2: 95 percent / LiAlH₄ / diethyl ether

3: 90 percent / Et₃N / CH₂Cl₂

4: 98 percent / NaN₃ / dimethylformamide / Heating

5: 86 percent / H₂ / Pd/C / 760 Torr

With potassium hydroxide; lithium aluminium tetrahydride; sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-2005-871963