[(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol

Base Information

• Chemical Name: [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol
• CAS No.: 211253-49-5
• Molecular Formula: C₂₀H₂₄O₄
• Molecular Weight: 328.408

Synonyms:[(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol

Chemical Property of [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol

Chemical Property:

Purity/Quality:

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Technology Process of [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol

There total 2 articles about [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1S,2S,3S,4S)-3,4-Bis-(2-methoxy-phenyl)-cyclobutane-1,2-dicarboxylic acid dimethyl ester (110456-56-9) → [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol (211253-49-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1055/s-2005-871963

Reference yield:

anti head-to-head coumarin dimer (5248-12-4) → [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol (211253-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq. KOH / acetone

2: 95 percent / LiAlH₄ / diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; In diethyl ether; acetone;

DOI:10.1055/s-2005-871963

Reference yield: 90.0%

methanesulfonyl chloride (124-63-0) + [(1S,2S,3S,4S)-2-Hydroxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methanol (211253-49-5) → Methanesulfonic acid (1S,2S,3S,4S)-2-methanesulfonyloxymethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutylmethyl ester

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1055/s-2005-871963

upstream raw materials:

(1S,2S,3S,4S)-3,4-Bis-(2-methoxy-phenyl)-cyclobutane-1,2-dicarboxylic acid dimethyl ester

anti head-to-head coumarin dimer

Downstream raw materials:

C-[(1S,2S,3S,4S)-2-Aminomethyl-3,4-bis-(2-methoxy-phenyl)-cyclobutyl]-methylamine

C₂₀H₂₂N₆O₂

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