1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine

Base Information

• Chemical Name: 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine
• CAS No.: 125330-79-2
• Molecular Formula: C₁₉H₂₁NO₂S
• Molecular Weight: 327.447
• Mol file: 125330-79-2.mol

Synonyms:1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine

Chemical Property of 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine

There total 4 articles about 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(phenyl)pyrrolidine (1006-64-0) + 2-hydroxy-2-(4-methylthiophenyl)ethanoic acid (109086-16-0) → 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine (125330-79-2)

Guidance literature:

With toluene-4-sulfonic acid; In xylene;

DOI:10.1016/S0968-0896(01)00117-1

Reference yield:

2-phenyl-1-pyrroline (700-91-4) → 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine (125330-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: 83 percent / TsOH / xylene

With sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; xylene;

DOI:10.1016/S0968-0896(01)00117-1

Reference yield:

benzoic acid ethyl ester (93-89-0,99341-95-4) → 1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine (125330-79-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: NaBH₄ / ethanol

3: 83 percent / TsOH / xylene

With sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; xylene;

DOI:10.1016/S0968-0896(01)00117-1

upstream raw materials:

2-(phenyl)pyrrolidine

2-hydroxy-2-(4-methylthiophenyl)ethanoic acid

2-phenyl-1-pyrroline

benzoic acid ethyl ester

Downstream raw materials:

6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

trans-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline

cis-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline