1-(Benzenesulfonyl)indol-4-amine

Base Information

• Chemical Name: 1-(Benzenesulfonyl)indol-4-amine
• CAS No.: 100557-22-0
• Molecular Formula: C14H12 N2 O2 S
• Molecular Weight: 272.327
• DSSTox Substance ID: DTXSID40543926
• Wikidata: Q82420895
• Mol file: 100557-22-0.mol

Synonyms:100557-22-0;1-(BENZENESULFONYL)INDOL-4-AMINE;1-(Phenylsulfonyl)-1H-indol-4-amine;4-amino-1-(phenylsulfonyl)indole;1-(Benzenesulfonyl)-1H-indol-4-amine;4-AMINO-1-(PHENYLSULFONYL)-INDOLE;1H-Indol-4-amine,1-(phenylsulfonyl)-;SCHEMBL5746143;DTXSID40543926;XQPCIFQSPLEMHI-UHFFFAOYSA-N;1-benzenesulfonyl-1H-indol-4-ylamine;AKOS015911573

Chemical Property of 1-(Benzenesulfonyl)indol-4-amine

Chemical Property:

• PSA: 73.47000
• LogP: 4.12250
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 272.06194880
• Heavy Atom Count: 19
• Complexity: 412

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)(=O)N2C=CC3=C(C=CC=C32)N

Technology Process of 1-(Benzenesulfonyl)indol-4-amine

There total 4 articles about 1-(Benzenesulfonyl)indol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-nitro-1-(phenylsulfonyl)-1H-indole (850655-62-8) → 1-(phenylsulfonyl)-1H-indol-4-amine (100557-22-0)

Guidance literature:

With hydrogenchloride; copper(II) sulfate; zinc; In tetrahydrofuran; methanol; water; for 1h; Inert atmosphere;

Reference yield: 92.0%

1-benzenesulfonyl-5-chloro-4-oxo-4,5,6,7-tetrahydroindole (95969-08-7) → 1-(phenylsulfonyl)-1H-indol-4-amine (100557-22-0)

Guidance literature:

With ammonium acetate; acetic acid; In xylene; for 2.5h; Heating;

Reference yield:

4-nitro-1H-indoIe (4769-97-5) → 1-(phenylsulfonyl)-1H-indol-4-amine (100557-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 0 - 80 °C

2: iron; ammonium chloride / methanol / 15 h / Reflux

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;

upstream raw materials:

1-benzenesulfonyl-5-chloro-4-oxo-4,5,6,7-tetrahydroindole

4-nitro-1-(phenylsulfonyl)-1H-indole

4-nitro-1H-indoIe

benzenesulfonyl chloride

Downstream raw materials:

N-(1-benzenesulfonyl-1H-indol-4-yl)-2-bromoacetamide

6-(1-benzenesulfonyl-1H-indol-4-ylamino)-2-chloro-5-nitro-pyrimidine-4-carboxylic acid methyl ester