5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

Base Information

Chemical Name:5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride
CAS No.:1101119-53-2
Molecular Formula:C₂₃H₂₃N₇O₄S*ClH
Molecular Weight:530.007
Hs Code.:

Synonyms:5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

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Chemical Property of 5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

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Technology Process of 5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

There total 4 articles about 5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 622-40-2
2-(morpholin-4-yl)ethanol

: 1101119-45-2
5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methylbenzenesulfonohydrazide

: 1101119-53-2
5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

Guidance literature:: 2-(morpholin-4-yl)ethanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methylbenzenesulfonohydrazide; In tetrahydrofuran; for 1h;

With hydrogenchloride; In methanol; dichloromethane; for 0.5h;
DOI:10.1016/j.bmcl.2016.11.078

Reference yield: 71.0%

: 1101119-53-2
5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

Guidance literature:

Reference yield:

: 1101120-80-2
5-cyano-2-fluorobenzene-1-sulfonyl chloride

: 1101119-53-2
5-cyano-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N-methyl-2-(2-morpholinoethoxy)benzenesulfonohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / methanol / 0.5 h

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 1 h

2.3: 0.5 h

With 2,6-dimethylpyridine; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2016.11.078