BOC-PHE(4-NHAC)-OH

Base Information

• Chemical Name: BOC-PHE(4-NHAC)-OH
• CAS No.: 114117-42-9
• Molecular Formula: C16H22 N2 O5
• Molecular Weight: 322.36
• Hs Code.: 2924299090
• Mol file: 114117-42-9.mol

Synonyms:N-ALPHA-T-BUTOXYCARBONYL-4-ACETAMIDO-L-PHENYLALANINE;(S)-N-ALPHA-T-BUTYLOXYCARBONYL-4-ACETYLAMINOPHENYLALANINE;BOC-4-(ACETYL-AMINO)-L-PHENYLALANINE;BOC-S-PHE-(4-NHAC)-OH;BOC-PHE(4-NHAC)-OH;BOC-L-PHE(4-NH-AC)

Chemical Property of BOC-PHE(4-NHAC)-OH

Chemical Property:

• Boiling Point: 564.9±50.0 °C(Predicted)
• PKA: 3.90±0.10(Predicted)
• PSA: 104.73000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 2.62930
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-K-4-acetamidophen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-PHE(4-NHAC)-OH

There total 1 articles about BOC-PHE(4-NHAC)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetoxysuccinimide (14464-29-0,57212-69-8) + L-N-tert-butoxycarbonyl-p-aminophenylalanine (55533-24-9,164332-89-2) → N-Boc-L-p-acetylamido-phenylalanine (114117-42-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 48h;

DOI:10.1021/ja025872a

Reference yield:

chloroacetonitrile (107-14-2) + N-Boc-L-p-acetylamido-phenylalanine (114117-42-9) → p-N-acetylamido-L-phenylalanine cyanomethyl ester hydrochloride salt

Guidance literature:

chloroacetonitrile; N-Boc-L-p-acetylamido-phenylalanine; With triethylamine; In acetonitrile; for 16h;

With hydrogenchloride; In 1,4-dioxane; Further stages.;

DOI:10.1021/ja025872a

Reference yield:

N-Boc-L-p-acetylamido-phenylalanine (114117-42-9) → C35H49N7O8S2

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine; PS-carbodiimide resin / CH₂Cl₂; dimethylformamide / 0.25 h

2: PS-DIEA resin / CH₂Cl₂; dimethylformamide / 3.5 h

With PS-carbodiimide resin; PS-DIEA resin; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm030130t

upstream raw materials:

N-acetoxysuccinimide

L-N-tert-butoxycarbonyl-p-aminophenylalanine

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