(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Base Information

Chemical Name:(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide
CAS No.:455312-11-5
Molecular Formula:C₂₇H₄₁N₃O₅Sn
Molecular Weight:606.35
Hs Code.:

Synonyms:(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

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Chemical Property of (R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

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Technology Process of (R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

There total 1 articles about (R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1461-22-9
tributyltin chloride

: 211619-36-2
N-methyl-N-(2-nitrobenzyl)carbamoyl chloride

: 455312-10-4
(R)-5-(3-Trimethylsilanyl-prop-2-ynyl)-oxazolidin-2-one

: 455312-11-5
(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Guidance literature:: With tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; lithium hexamethyldisilazane; In not given;
DOI:10.1021/ja027121e

Reference yield:

: 455312-11-5
(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

: 455312-14-8
1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: CH₂Cl₂ / 1 h / -42 °C

2.1: 1,2-dimethoxy-ethane / 0.08 h / Heating

3.1: ethanol / 120 h / Heating

4.1: pyridine; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 48 h / 30 - 55 °C

5.1: Cs₂CO₃ / methanol / 18 h / 20 °C

6.1: dimethyl sulfoxide; oxalyl chloride / CH₂Cl₂ / 0.22 h / -78 - 20 °C

6.2: Et₃N / CH₂Cl₂ / -78 - 20 °C

With pyridine; dmap; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; 6.1: Swern oxidation;
DOI:10.1021/jo026287v

Reference yield:

: 455312-11-5
(R)-2-Oxo-5-(3-tributylstannanyl-prop-2-ynyl)-oxazolidine-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

: 455312-08-0
(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1 h / -42 °C

2: 1,2-dimethoxy-ethane / 0.08 h / Heating

3: ethanol / 120 h / Heating

4: pyridine; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 48 h / 30 - 55 °C

With pyridine; dmap; In 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo026287v