(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

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Chemical Name:(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide
CAS No.:455312-08-0
Molecular Formula:C₃₄H₃₂N₆O₁₀S
Molecular Weight:716.728
Hs Code.:

(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Synonyms:(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

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Chemical Property of (3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

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Technology Process of (3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

There total 11 articles about (3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5427-82-7
1H-pyrrole-2-carbonyl chloride

: 474671-05-1
(3aS,4S,5S,6aR)-4-(2-Nitro-benzylamino)-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

: 455312-08-0
(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Guidance literature:: With pyridine; dmap; In 1,2-dichloro-ethane; at 30 - 55 ℃; for 48h;
DOI:10.1021/jo026287v

Reference yield:

: 143724-89-4
Trimethyl-((R)-3-oxiranyl-prop-1-ynyl)-silane

: 455312-08-0
(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaN₃; NH₄Cl

1.2: 67 percent / nBuLi; PMe₃

2.1: NaNTMS₂

3.1: n-Bu₄NF

4.1: n-Bu₃SnCl; LiNTMS₂

4.2: -42 °C

5.1: 34 percent / n-Bu₃SnCl / 1,2-dimethoxy-ethane / Heating

6.1: Et₃N

With sodium azide; tributyltin chloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; ammonium chloride; triethylamine; lithium hexamethyldisilazane; In 1,2-dimethoxyethane;
DOI:10.1021/ja027121e

Reference yield:

: 455312-10-4
(R)-5-(3-Trimethylsilanyl-prop-2-ynyl)-oxazolidin-2-one

: 455312-08-0
(3aS,4S,5S,6aR)-4-[(2-Nitro-benzyl)-(1H-pyrrole-2-carbonyl)-amino]-2-oxo-5-(toluene-4-sulfonyl)-tetrahydro-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaNTMS₂

2.1: n-Bu₄NF

3.1: n-Bu₃SnCl; LiNTMS₂

3.2: -42 °C

4.1: 34 percent / n-Bu₃SnCl / 1,2-dimethoxy-ethane / Heating

5.1: Et₃N

With tributyltin chloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; lithium hexamethyldisilazane; In 1,2-dimethoxyethane;
DOI:10.1021/ja027121e