4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

Base Information

Chemical Name:4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide
CAS No.:121653-86-9
Molecular Formula:C₂₇H₃₂N₄O₇
Molecular Weight:524.574
Hs Code.:

Synonyms:4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

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Chemical Property of 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

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Technology Process of 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

There total 7 articles about 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 121653-85-8
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

: 121653-86-9
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; for 192h;
DOI:10.1021/jm00128a032

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 121653-86-9
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 5.07 g / benzene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

3: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

4: MeOH, NaOMe / 2.5 h

5: tetrahydrofuran; dioxane / 4.5 h / Heating

6: 89 percent / 1.0 N LiOH / tetrahydrofuran; H₂O / 4.5 h

7: 72 percent / EEDQ, Et₃N / CH₂Cl₂ / 192 h

With methanol; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sodium methylate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jm00128a032

Reference yield:

: 121653-72-3
(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

: 121653-86-9
4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

3: MeOH, NaOMe / 2.5 h

4: tetrahydrofuran; dioxane / 4.5 h / Heating

5: 89 percent / 1.0 N LiOH / tetrahydrofuran; H₂O / 4.5 h

6: 72 percent / EEDQ, Et₃N / CH₂Cl₂ / 192 h

With methanol; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; sodium methylate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; tin(IV) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm00128a032