N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Base Information

Chemical Name:N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide
CAS No.:99694-57-2
Molecular Formula:C₂₂H₂₈N₄O₅
Molecular Weight:428.488
Hs Code.:

Synonyms:N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Chemical Property of N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Technology Process of N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

There total 9 articles about N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 99694-55-0
{Cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-acetic acid methyl ester

: 99694-57-2
N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: With sodium hydroxide; In methanol; for 0.5h; Ambient temperature;
DOI:10.1021/jm00385a012

Reference yield:

: 40447-13-0
N-cyclohexylglycine methyl ester

: 99694-57-2
N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) AcONa / methanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: H₂ / 10percent Pd/C / ethanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

6: 92 percent / aq. NaOH / methanol / 0.5 h / Ambient temperature

With dmap; ammonium hydroxide; sodium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00385a012

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 99694-57-2
N-carboxymethyl-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: DBU / tetrahydrofuran

2: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) AcONa / methanol / 0.5 h

4: NaBH₃CN / ethanol / 3 h

5: H₂ / 10percent Pd/C / ethanol

6: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

7: 92 percent / aq. NaOH / methanol / 0.5 h / Ambient temperature

With dmap; ammonium hydroxide; sodium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00385a012