(S)-(+)-1-(4'-methyl)phenyl-2-propanamine

Base Information

• Chemical Name: (S)-(+)-1-(4'-methyl)phenyl-2-propanamine
• CAS No.: 81601-14-1
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.236

Synonyms:(S)-(+)-1-(4'-methyl)phenyl-2-propanamine

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Chemical Property of (S)-(+)-1-(4'-methyl)phenyl-2-propanamine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(+)-1-(4'-methyl)phenyl-2-propanamine

There total 8 articles about (S)-(+)-1-(4'-methyl)phenyl-2-propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-methylamphetamine (64-11-9,22683-78-9) → (S)-(+)-1-(4'-methyl)phenyl-2-propanamine (81601-14-1,22683-78-9)

Guidance literature:

With ethyl 2-methoxyacetate; Candida antartica lipase B; triethylamine; at 35 ℃; optical yield given as %ee; Enzymatic reaction;

DOI:10.1039/c1ob06251d

Reference yield: 42.0%

ethyl 2-methoxyacetate (3938-96-3) + 4-methylamphetamine (64-11-9,22683-78-9) → (R)-(-)-1-(4'-methyl)phenyl-2-propanamine (788775-45-1,22683-78-9) + (S)-(+)-1-(4'-methyl)phenyl-2-propanamine (81601-14-1,22683-78-9) + (R)-N-[2-(4'-methylphenyl)-1-methylethyl]-2-methoxyacetamide (1351781-79-7)

Guidance literature:

With Candida antartica lipase B; triethylamine; In n-heptane; at 35 ℃; for 2.5h; optical yield given as %ee; Inert atmosphere; Enzymatic reaction;

DOI:10.1039/c1ob06251d

Reference yield:

1-(p-tolyl)-2-nitropropene (52287-56-6,29816-55-5) → (S)-(+)-1-(4'-methyl)phenyl-2-propanamine (81601-14-1,22683-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 3 h / Inert atmosphere; Reflux

2: Candida antartica lipase B; triethylamine / n-heptane / 2.5 h / 35 °C / Inert atmosphere; Enzymatic reaction

With lithium aluminium tetrahydride; Candida antartica lipase B; triethylamine; In diethyl ether; n-heptane;

DOI:10.1039/c1ob06251d

upstream raw materials:

ethyl 2-methoxyacetate

4-methylamphetamine

1-(p-tolyl)-2-nitropropene

4-methyl-benzaldehyde

Downstream raw materials:

(S)-N-(1-p-tolylpropan-2-yl)acetamide