4-Methylamphetamine

Base Information

• Chemical Name: 4-Methylamphetamine
• CAS No.: 64-11-9
• Deprecated CAS: 22683-78-9
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• UNII: 9E273KL7HS
• DSSTox Substance ID: DTXSID50945351
• Nikkaji Number: J11.031K
• Wikipedia: 4-Methylamphetamine
• Wikidata: Q685310
• Metabolomics Workbench ID: 124009
• ChEMBL ID: CHEMBL166183
• Mol file: 64-11-9.mol

Synonyms:1-(4-methylphenyl)propane-2-amine;4-methyl-amphetamine;4-methylamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 4-Methylamphetamine

Chemical Property:

• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 232℃
• PKA: 10.06±0.10(Predicted)
• Flash Point: 99 ºC
• PSA: 26.02000
• Density: 0.938
• LogP: 2.58500
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 103

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)CC(C)N

Technology Process of 4-Methylamphetamine

There total 8 articles about 4-Methylamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-4-(prop-1-enyl)benzene (2698-14-8) → 4-methylamphetamine (64-11-9,22683-78-9)

Guidance literature:

With 10-phenyl-9-(2,4,6-trimethylphenyl)acridinium tetrafluoroborate; ammonium carbonate; 2-amino-benzenethiol; In dichloromethane; chlorobenzene; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202016679

Reference yield: 71.0%

1-(p-tolyl)-2-nitropropene (52287-56-6,29816-55-5) → 4-methylamphetamine (64-11-9,22683-78-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Inert atmosphere; Reflux;

DOI:10.1039/c1ob06251d

Reference yield: 60.0%

p-Tolylaceton (2096-86-8) + ammonium acetate (631-61-8,92206-38-7) → 4-methylamphetamine (64-11-9,22683-78-9)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 24h;

DOI:10.1002/adsc.202100351

upstream raw materials:

1-(p-tolyl)-2-nitropropene

1-(4-methylphenyl)propan-2-one oxime

p-Tolylaceton

formamide

Downstream raw materials:

(R)-(-)-1-(4'-methyl)phenyl-2-propanamine

(S)-(+)-1-(4'-methyl)phenyl-2-propanamine

(R)-N-[2-(4'-methylphenyl)-1-methylethyl]-2-methoxyacetamide

N-[2-(4'-methylphenyl)-1-methylethyl]-2-methoxyacetamide