4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid

Base Information

• Chemical Name: 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid
• CAS No.: 182621-49-4
• Molecular Formula: C₁₉H₂₃Cl₂NO₄
• Molecular Weight: 400.302
• Mol file: 182621-49-4.mol

Synonyms:4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid

Chemical Property of 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid

There total 3 articles about 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 2-(3,4-dichloro-phenyl)-5-(tetrahydro-pyran-2-yl-oxy)-pentanenitrile (146395-96-2) → 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid (182621-49-4)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol; for 8h; Heating;

DOI:10.1016/0960-894X(96)00419-2

Reference yield:

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide (33821-94-2) → 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid (182621-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH / tetrahydrofuran

2: 73 percent / triton B / methanol / 8 h / Heating

With N-benzyl-trimethylammonium hydroxide; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/0960-894X(96)00419-2

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid (182621-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH / tetrahydrofuran

2: 73 percent / triton B / methanol / 8 h / Heating

With N-benzyl-trimethylammonium hydroxide; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/0960-894X(96)00419-2

upstream raw materials:

acrylic acid methyl ester

2-(3,4-dichloro-phenyl)-5-(tetrahydro-pyran-2-yl-oxy)-pentanenitrile

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

3,4-dichloro-benzeneacetonitrile

Downstream raw materials:

Acetic acid 3-[3-(3,4-dichloro-phenyl)-2,6-dioxo-piperidin-3-yl]-propyl ester

(S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide

{3-(3,4-Dichloro-phenyl)-3-[3-(4-methylamino-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-phenyl-methanone

(+)-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)-piperidine