[(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid

Base Information

• Chemical Name: [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid
• CAS No.: 936227-62-2
• Molecular Formula: C₁₉H₂₄NO₆P
• Molecular Weight: 393.376
• Mol file: 936227-62-2.mol

Synonyms:[(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid

Chemical Property of [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid

There total 3 articles about [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid diethyl ester (936227-54-2) → [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid (936227-62-2)

Guidance literature:

[(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid diethyl ester; With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃;

With water; In acetonitrile; for 1h;

DOI:10.1016/j.bmcl.2006.12.050

Reference yield:

tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate (167486-39-7) → [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid (936227-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 83 percent / TFA / CH₂Cl₂ / 3 h

2.1: 74 percent / Et₃N; DCC; HOBt / CH₂Cl₂; tetrahydrofuran

3.1: TMSBr / acetonitrile / 0 - 20 °C

3.2: 98 percent / H₂O / acetonitrile / 1 h

With trimethylsilyl bromide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.12.050

Reference yield:

1,3-bis(benzyloxy)propan-2-amine (132819-08-0) → [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid (936227-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 74 percent / Et₃N; DCC; HOBt / CH₂Cl₂; tetrahydrofuran

2.1: TMSBr / acetonitrile / 0 - 20 °C

2.2: 98 percent / H₂O / acetonitrile / 1 h

With trimethylsilyl bromide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.12.050

upstream raw materials:

[(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid diethyl ester

tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate

1,3-bis(benzyloxy)propan-2-amine