167486-39-7

Upstream product

• 100-39-0 benzyl bromide 
• 125414-41-7 N-Boc-serinol 
• 144570-06-9 N-TERT-BUTOXYCARBONYL-O-BENZYL-(D)-VALINOL 
• 865-47-4 potassium tert-butylate 
• 79069-15-1 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 936227-54-2 [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid diethyl ester 
• 936227-62-2 [(2-benzyloxy-1-benzyloxymethyl-ethylcarbamoyl)-methyl]-phosphonic acid 
• 1381872-65-6 C₁₈H₂₁NO₃ 
• 1381873-23-9 C₃₂H₄₀N₂O₅ 
• 1381873-21-7 C₃₁H₃₈N₂O₅ 
• 1381873-19-3 C₃₂H₄₀N₂O₅ 
• 1381873-17-1 C₃₃H₄₂N₂O₅ 
• 1381873-13-7 C₃₃H₄₂N₂O₅ 
• 1381872-91-8 C₃₇H₄₈N₂O₇ 
• 1381872-89-4 C₃₆H₄₆N₂O₇ 
• 1381872-87-2 C₃₇H₄₈N₂O₇ 
• 1381872-85-0 C₃₈H₅₀N₂O₇ 
• 1381872-81-6 C₃₈H₅₀N₂O₇ 
• 1381872-75-8 C₁₈H₁₉NO₂ 

Relevant academic research and scientific papers

OPIOID AGONISTS AND USES THEREOF

Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors

Novel branched isocyanides have been prepared from l-serine and used as building blocks in the Passerini-amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease.

Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase

A series of inhibitors of the aspartate transcarbamoylase, an enzyme involved in pyrimidine nucleotide biosynthesis, has been synthesized. These inhibitors are analogues of a highly potent inhibitor of this enzyme, N-phosphonacetyl-l-aspartate (PALA). Analogues have been synthesized with modifications at the α- and β-carboxylates as well as at the aspartate moiety. The ability of these compounds to inhibit the enzyme was evaluated. These studies, with functional group modified PALA derivatives, showed that amide groups can be a useful substitute of the carboxylate in order to reduce the charge on the molecule, and indicate that the relative position of the functional group in the β-position is more critical than the nature of the functional group. Some of the molecules synthesized here are potent inhibitors of the enzyme.

Difluoro statone analogs

This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.