(R)-1-phenylethylamine hydrochloride

Base Information

• Chemical Name: (R)-1-phenylethylamine hydrochloride
• CAS No.: 10277-86-8
• Molecular Formula: C₈H₁₂N*Cl
• Molecular Weight: 157.643
• Mol file: 10277-86-8.mol

Synonyms:(R)-1-phenylethylamine hydrochloride

Chemical Property of (R)-1-phenylethylamine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-phenylethylamine hydrochloride

There total 13 articles about (R)-1-phenylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyllithium (917-54-4) + N-[(4R,5R)-4,5-diphenyl-1,3-dioxolan-2-yl]-N-[(1E)-phenylmethylene]amine (528818-99-7) → (R,R)-hydroxybenzoin (52340-78-0) + (R)-1-phenylethylamine hydrochloride (10277-86-8) + (S)-(-)-α-methylbenzylamine hydrochloride (17279-30-0)

Guidance literature:

methyllithium; N-[(4R,5R)-4,5-diphenyl-1,3-dioxolan-2-yl]-N-[(1E)-phenylmethylene]amine; In 1,2-dimethoxyethane; at -78 ℃; for 2h;

With hydrogenchloride; In methanol; at 20 ℃; for 10h; Title compound not separated from byproducts;

DOI:10.1021/jo026571m

Reference yield: 99.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) → (R)-1-phenylethylamine hydrochloride (10277-86-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 15 - 20 ℃; for 0.416667h;

DOI:10.1016/j.catcom.2016.10.008

Reference yield: 97.0%

(RS)-2-methyl-N-((R)-1-phenylethyl)propane-2-sulfinamide (247236-71-1) → tert-butylsulfinyl chloride (31562-43-3) + (R)-1-phenylethylamine hydrochloride (10277-86-8)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 0.583333h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.03.020

upstream raw materials:

methylmagnesium bromide

(R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide

N-α-phenylethylacetamide

methyllithium

Downstream raw materials:

(R,R)-(+)-α-<(1-phenylethyl)amino>-α-(p-tolyl)acetonitrile hydrochloride

(R,R)-(+)-α-<(1-phenylethyl)amino>-α-(4-methoxyphenyl)acetonitrile hydrochloride

(R,R)-(+)-α-<(1-phenylethyl)amino>-α-propionitrile hydrochloride

(R,R)-(+)-α-<(1-phenylethyl)amino>-α-butyronitrile hydrochloride