(1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester
• CAS No.: 134984-63-7
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.359
• Hs Code.: 2939799090
• Mol file: 134984-63-7.mol

Synonyms:(1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

Chemical Property of (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylicacid,2-[(1R)-1-phenylethyl]-,ethylester,(1S,3S,4R)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

There total 14 articles about (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester (37662-05-8) → (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester (134984-63-7)

Guidance literature:

With trifluoroacetic acid; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 74.0%

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester (37662-05-8) → (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester (134984-63-7) + endo-2-aza-2-<(R)-1-phenylethyl>-3-ethoxycarbonyl<2.2.1>bicyclohept-5-ene (135094-10-9)

Guidance literature:

((R)-1-phenyl-ethylimino)-acetic acid ethyl ester; With trifluoroacetic acid; In dichloromethane; at -78 ℃; for 0.166667h;

With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 0.166667h;

cyclopenta-1,3-diene; In dichloromethane; at -78 - 20 ℃; for 21h;

Reference yield: 74.0%

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester (37662-05-8) → ethyl (1R,3S,4S)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate + (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester (134984-63-7)

Guidance literature:

cyclopenta-1,3-diene; ((R)-1-phenyl-ethylimino)-acetic acid ethyl ester; With boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; at -78 - 20 ℃; for 21h;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

glyoxylic acid ethyl ester

(R)-1-phenylethylamine hydrochloride

cyclopenta-1,3-diene

((R)-1-phenyl-ethylimino)-acetic acid ethyl ester

Downstream raw materials:

ethyl (1R,3S,4S)-2-<(R)-1-phenylethyl>-2-azabicyclo<2.2.1>heptane-3-exo-carboxylate

(1R,3S,4S)-2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid ethyl ester