2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

Base Information

Chemical Name:2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine
CAS No.:853020-22-1
Molecular Formula:C₂₅H₃₂N₄O₂
Molecular Weight:420.555
Hs Code.:

Synonyms:2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

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Chemical Property of 2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

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Technology Process of 2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

There total 4 articles about 2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 853018-64-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]acetamide

: 853020-22-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating / reflux;

Reference yield:

: 66-83-1
5-methoxytryptamine hydrochloride

: 853020-22-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / 100 °C

1.2: 72 h

2.1: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

With lithium aluminium tetrahydride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 853020-88-9,853020-89-0,853020-91-4
1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853020-22-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;