N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

Base Information

Chemical Name:N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea
CAS No.:853018-51-6
Molecular Formula:C₂₈H₃₇N₅O₃
Molecular Weight:491.633
Hs Code.:

Synonyms:N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

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Chemical Property of N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

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Technology Process of N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

There total 4 articles about N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853020-22-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl] ethanamine

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 853018-51-6
N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

Guidance literature:: With potassium carbonate; In acetonitrile; at 75 ℃; for 16h;

Reference yield:

: 853020-88-9,853020-89-0,853020-91-4
1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853018-51-6
N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

5: potassium carbonate / acetonitrile / 16 h / 75 °C

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 853018-64-1
2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]acetamide

: 853018-51-6
N'-{2-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]ethyl}-N,N-dimethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Heating / reflux

2: potassium carbonate / acetonitrile / 16 h / 75 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;