3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

Base Information

Chemical Name:3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one
CAS No.:663918-96-5
Molecular Formula:C₃₂H₃₅NO₂S₃
Molecular Weight:561.833
Hs Code.:

Synonyms:3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

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Chemical Property of 3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

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Technology Process of 3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

There total 3 articles about 3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 121929-87-1
(R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone

: 180973-22-2
(2E)-5-[(triphenylmethyl)thio]-2-pentenal

: 663918-96-5
3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

: 663918-95-4
(3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one

Guidance literature:: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 2h;

(2E)-5-[(triphenylmethyl)thio]-2-pentenal; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ja039258q

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 663918-96-5
3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: benzene / 8 h / 85 °C

3.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 °C

3.2: 1 h / -78 °C

With titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene; 2.1: Wittig reaction;
DOI:10.1021/jm200432a

Reference yield:

: 150350-28-0
S-trityl 3-mercaptopropionaldehyde

: 663918-96-5
3R-hydroxy-1-(4R-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanylhept-4E-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzene / 8 h / 85 °C

2.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 °C

2.2: 1 h / -78 °C

With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene; 1.1: Wittig reaction;
DOI:10.1021/jm200432a