121929-87-1

Basic information

• Product Name: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone
• Synonyms: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone;(R)-3-Acetyl-4-isopropyl-1,3-thiazolidine-2-thione;1-[(4R)-4-(1-methylethyl)-2-thioxo-3-thiazolidinyl]-Ethanone
• CAS NO: 121929-87-1
• Molecular Formula: C₈H₁₃NOS₂
• Molecular Weight: 203.32492
• Mol File: 121929-87-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 280℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.22
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone(121929-87-1)
• EPA Substance Registry System: (R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone(121929-87-1)

Safety Data

• Hazardous Substances Data: 121929-87-1(Hazardous Substances Data)

Usage

General Description

The chemical compound "(R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone" is a thiazolidine derivative that contains a thioxothiazolidin-3-yl group and an isopropyl group attached to a ketone moiety. It is a chiral compound with the (R) configuration, indicating that it has a specific three-dimensional arrangement of atoms. Thiazolidine derivatives have been studied for their potential pharmaceutical applications, including as antidiabetic, antioxidant, and anti-inflammatory agents. The isopropyl group in the compound may contribute to its physical and chemical properties, affecting its solubility, stability, and reactivity. Overall, "(R)-1-(4-isopropyl-2-thioxothiazolidin-3-yl)ethanone" is a potentially biologically active compound that could be of interest for further research and development.

Upstream product

• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 640-68-6 D-Val-OH 
• 110199-16-1 4(R)-isopropyl-1,3-thiazolidine-2-thione 
• 75-36-5 acetyl chloride 

Downstream Products

• 663918-95-4 (3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one 
• 1621326-11-1 C₃₆H₃₇NO₂S₃ 
• 1621326-10-0 C₃₆H₃₇NO₂S₃ 
• 1591927-96-6 C₃₃H₅₇NO₆S₂Si 
• 1259556-83-6 C₁₈H₂₃NO₂S₂ 
• 1004518-23-3 C₁₆H₂₁NO₂S₂ 
• 1004518-10-8 C₁₆H₂₁NO₂S₂ 
• 950513-92-5 (3R,5S)-6-(tert-butyldiphenylsiloxy)-3-hydroxy-1-[(4'R)-4'-isopropyl-2'-thioxothiazolidin-3'-yl]-5-(4-methoxybenzyloxy)-hexan-1-one 
• 950513-93-6 (3S,5S)-6-(tert-butyldiphenylsiloxy)-3-hydroxy-1-[(4'R)-4'-isopropyl-2'-thioxothiazolidin-3'-yl]-5-(4-methoxybenzyloxy)-hexan-1-one 
• 929298-23-7 9-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-1-(4-isopropyl-2-thioxo-thiazolidin-3-yl)-4-methyl-5-triethylsilanyloxy-nonan-1-one 

Relevant articles and documents

Stereoselective total synthesis of ieodomycin C

A concise stereoselective synthesis of the marine natural product ieodomycin C (3) has been achieved from commercially available pyridinium-1-sulfonate (8) in eight linear steps and 14% overall yield. The key synthetic steps included a B-alkyl Suzuki-Miyaura cross-coupling reaction and an Evans-Nagao acetate aldol reaction. The same synthetic sequence was used for preparing the enantiomer of ieodomycin C (3). Our efforts confirmed the structure of the antibacterial natural product 3.

Total Syntheses of Disorazoles A1 and B1 and Full Structural Elucidation of Disorazole B1

Described herein are the first total syntheses of naturally occurring antitumor agents disorazoles A1 and B1 and the full structural assignment of the latter. The syntheses were achieved through convergent strategies employing enantioselective constructions of the required building blocks, including a novel Sharpless epoxidation/enzymatic kinetic resolution of stannane-containing substrates that led selectively to both enantiomeric forms of an epoxy vinyl stannane, and a series of coupling reactions, including a Wittig reaction, a Suzuki coupling, a Stille coupling, a Yamaguchi esterification and a Yamaguchi macrolactonization.

Highly diastereoselective alkylation of chiral tin(II) enolates onto cyclic acyl imines. An efficient assymetric synthesis of bicyclic alkaloids bearing a nitrogen atom ring juncture

-