(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1616404-12-6
Molecular Formula:C₂₂H₂₀N₂O₅
Molecular Weight:392.411
Hs Code.:

Synonyms:(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of (E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of (E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 4 articles about (E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-[(E)-2-(4-Methoxy-phenyl)-vinylcarbamoyl]-malonic acid diethyl ester

: 1616404-12-6
(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: In diphenylether; at 200 - 210 ℃; for 0.0833333h;
DOI:10.1080/00397911.2013.878360

Reference yield:

: 83421-79-8
p-methoxycinnamoyl azide

: 1616404-12-6
(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzine / Reflux

2.1: sodium hydride / toluene; mineral oil

2.2: 2 h / 0 - 20 °C

3.1: diphenylether / 0.08 h / 200 - 210 °C

With sodium hydride; In diphenylether; benzine; toluene; mineral oil; 1.1: |Curtius Rearrangement;
DOI:10.1080/00397911.2013.878360

Reference yield:

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1616404-12-6
(E)-4-hydroxy-5-(4-methoxyphenyl)-N-(4-methoxystyryl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 3 h / 20 °C / Cooling with ice

2.1: benzine / Reflux

3.1: sodium hydride / toluene; mineral oil

3.2: 2 h / 0 - 20 °C

4.1: diphenylether / 0.08 h / 200 - 210 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; In diphenylether; benzine; toluene; mineral oil; 2.1: |Curtius Rearrangement;
DOI:10.1080/00397911.2013.878360