N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1345855-17-5
Molecular Formula:C₂₅H₁₇BrF₃N₃O₄
Molecular Weight:560.327
Hs Code.:

Synonyms:N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 10 articles about N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 1225278-74-9
4-(3-bromopyridin-4-yloxy)-2,5-difluorobenzenamine

: 1345855-09-5
4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

: 1345855-17-5
N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: 4-(3-bromopyridin-4-yloxy)-2,5-difluorobenzenamine; 4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

With sodium carbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1345855-17-5
N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 120 - 130 °C

2.1: 2 h / 70 °C

3.1: acetic acid / Reflux

3.2: pH ~ 9 - 10

4.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C

5.1: water; lithium hydroxide / ethanol / 16 h / 25 °C

5.2: pH < 2

6.1: thionyl chloride / 1 h / 60 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C

With pyridine; thionyl chloride; water; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1345855-17-5
N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2 h / 70 °C

2.1: acetic acid / Reflux

2.2: pH ~ 9 - 10

3.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C

4.1: water; lithium hydroxide / ethanol / 16 h / 25 °C

4.2: pH < 2

5.1: thionyl chloride / 1 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C

With pyridine; thionyl chloride; water; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane;