4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

Base Information

Chemical Name:4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid
CAS No.:1355092-75-9
Molecular Formula:C₂₃H₂₅Cl₂NO₄
Molecular Weight:450.362
Hs Code.:

Synonyms:4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

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Chemical Property of 4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

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Technology Process of 4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

There total 9 articles about 4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₂₇H₃₃Cl₂NO₄

: 1355092-75-9
4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2017.12.018

Reference yield:

: 1355089-42-7
tert-butyl 4-{6-hydroxy-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoate

: 1355092-75-9
4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

2: hydrogenchloride / water; 1,4-dioxane / 48 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018

Reference yield:

: 1355087-61-4
1'-benzyl-2H-spiro(1-benzofuran-3,4'-piperidin)-6-ol

: 1355092-75-9
4-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium(II) hydroxide; hydrogenchloride / water; methanol / 48 h / 20 °C

2: potassium carbonate / acetonitrile / 16 h / 65 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

4: hydrogenchloride / water; 1,4-dioxane / 48 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; palladium(II) hydroxide; potassium carbonate; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018