(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol

Base Information

• Chemical Name: (1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol
• CAS No.: 158984-76-0
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• European Community (EC) Number: 817-547-3
• DSSTox Substance ID: DTXSID20460480
• Nikkaji Number: J2.535.916J
• Wikidata: Q82284534
• Mol file: 158984-76-0.mol

Synonyms:(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol;158984-76-0;1-Benzyl-4-(hydroxymethyl)-1,2,3,6-tetrahydropyridine;(1-benzyl-3,6-dihydro-2H-pyridin-4-yl)methanol;MFCD16620244;SCHEMBL325460;DTXSID20460480;KWEISZMWJPDOFR-UHFFFAOYSA-N;4-Pyridinemethanol, 1,2,3,6-tetrahydro-1-(phenylmethyl)-;AB6331;AKOS016007127;AS-44761;SY026968;CS-0447482;EN300-142592;A883333;1-benzyl-4-hydroxymethyl-1,2,3,6-tetrahydropyridine;(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methanol;1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol;1,2,3,6-tetrahydro-1-(phenylmethyl)4-pyridinemethanol;(1-benzyl-1, 2, 3, 6-tetrahydro-pyridin-4-yl)-methanol

Chemical Property of (1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 203.131014166
• Heavy Atom Count: 15
• Complexity: 219

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CC=C1CO)CC2=CC=CC=C2

Technology Process of (1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol

There total 8 articles about (1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C13H14ON(1+)*Br(1-) → 1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol (158984-76-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 3h;

DOI:10.1080/00397910701483944

Reference yield: 81.0%

pyridine-4-methanol (586-95-8) + benzyl chloride (100-44-7) → 1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol (158984-76-0)

Guidance literature:

pyridine-4-methanol; benzyl chloride; In methanol; for 24h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

Reference yield: 64.0%

pyridine-4-methanol (586-95-8) + benzyl bromide (100-39-0) → 1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinemethanol (158984-76-0)

Guidance literature:

pyridine-4-methanol; benzyl bromide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

With sodium tetrahydroborate; ethanol; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Reflux;

upstream raw materials:

1-benzyl-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid ethyl ester

pyridine-4-methanol

benzyl bromide

benzyl chloride

Downstream raw materials:

trans-1-(phenyl-methyl)-3-hydroxy-4-piperidinemethanol

1-benzyl-4-benzyloxymethyl-1,2,3,6-tetrahydropyridine

1-benzyl-4-(4-chloro-2-iodo-phenoxymethyl)-1,2,3,6-tetrahydro-pyridine

1-(phenylmethyl)-4-[(tert-butyldimethylsilanyloxy)methyl]-1,2,3,6-tetrahydropyridine